Biopsy Examination for Breast Cancer

Microscopic examination of tumor samples that can describe the histopathological of cell-structure of the suspected cancer tissue.


It also determines a person can be convicted of getting cancer or not. It is strongly influenced at all when taking biopsy material, it can represent the whole condition of the tumor or not.
There are several ways taking biopsies. This can be selected withconsideration of the location of the tumor, the effectiveness ofretrieval, the facilities available and the possibility of radicalismtumor itself.
Known to exist: an open biopsy (excision, and incisional biopsy),biopsy needles, trucut biopsy, punch biopsy, and curettage biopsy (biopsy scrapings). From this examination can be determined the type, nature of tumor cells, and levels of differentiation (a change) so that cells from the normal structure could be known just how fierce the tumor cells.
From this information the doctor can predict the outcome of therapythat will be given.
To do a biopsy examine can be performed before major surgery done(which is more recommended), or it could be at the time of surgeryas a therapeutic effort.

The most important thing in mind that whatever the outcome, the patient has the right to know and get the results of the pathology examination.

And by the way individual doctors must inform it directly to the patient. If the results of the biopsy came back positive cancer, a doctor may recommend a biopsy will be performed one week after treatment forcancer.Accuracy also depends on the accuracy of biopsies and the experience of the surgeon Pathology.
And the dangers if delayed much longer.

There is no certainty whether the biopsy can make the cancer cellsspread more rapidly or not.
There are doctors who say yes, there is also a doctor who said no.but one thing is for sure "neddle test" does not make the cancercells spread.

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Recognize Early Symptoms of Breast Cancer





Cause
The cause is unknown, but there are some risk factors that cause a woman to be more likely to suffer from breast cancer.

Risk Factors
Some of the factors that influence risk are:

  1. Age. About 60% of breast cancers occur in over 60 years. The greatest risk found in women aged over 75 years.
  2. Ever had breast cancer.  After the affected breast removed, then the risk of breast cancer ina healthy increase of 0.5-1% / year.
  3. Family history of breast cancer.  Women who are mothers, sisters or children suffering from cancer, had a three times greater risk for breast  cancer.
  4. Genetic and hormonal factors.
  5. Had suffered from non-cancerous breast disease.
  6. Menarche (first menstruation) before age 12 years, menopauseafter age 55 years, first pregnancy after age 30 years or had never been pregnant.
  7. Use of birth control pills or estrogen replacement therapy.
  8. Obesity after menopause.
  9. The use of alcohol.
  10. The use of alcohol more than 1-2 cups / day can increase the risk of breast cancer.
  11. Chemicals.  Several studies have mentioned the chemical exposure that mimicestrogen (which is contained in pesticides and other industrial products) may increase the risk of breast cancer.
  12. DES (diethylstilbestrol).  Women who took DES to prevent miscarriage have a higher risk ofbreast cancer.
  13. Irradiation.
Here are some types of lumps that can be found in the breast.

FibroadenomaFibroadenoma is a round shaped mass, demarcated, rubbery,which arise due to excessive growth of glandular tissue andconnective tissue.
These lumps are benign and usually painless. Lump fibroadenomacan be moved or be shifted if the breast is pressed.
Fibroadenoma responds to hormonal changes and tend to enlargeduring pregnancy and shrink after menopause.
Any woman can suffer from fibroadenoma, but usually most often found at the age of 20 to 30 years.
Fibroadenomas can not be definitely diagnosed only by physical examination alone.
Mammography and breast ultrasound can help make a diagnosis,but the only way to ensure a fibroadenoma is by biopsyexamination, which is taking a bit of tissue with a needle andexamined under a microscope.
Fibroadenoma may disappear spontaneously.
But if you persist, or the more enlarged, or the patient is veryworried about these lumps, it can be done surgically.

Breast abscessBreast abscess usually occurs as a complication of breast infection(mastitis). These infections most often occur during breastfeeding,due to the entry of bacteria into the breast tissue.
Breast infections are usually treated by administering antibitiotik. Ifantibiotics are not able to overcome infection or breast abscess,surgical removal can be a breast abscess.

Breast injuryBreast injury due to surgery or an accident for example, may interfere with the so-called fat necrosis.
Fat necrosis may further lead to the formation of lumps of connective tissue demarcated, round, and can be driven. If the injury has long been the case, the lump is usually painless.
But if the injury has just happened, can there is pain and swelling onthe skin over the bumps.
Breast lumps due to fat necrosis usually disappears by itself. But ifthe lump persists, you should immediately see a doctor.
Tumor FillodesFillodes tumor is a breast lump that is not pain due to excessivegrowth of connective tissue.
Fillodes tumors generally are benign, although some of them may be malignant.
Often, medical practitioners is difficult to distinguish between tumorand fibroadenoma fillodes - even after the imaging examinations(mammography or breast ultrasound) and fine needle aspirationbiopsy.
One sign that the lump was a tumor fillodes is growing very fast andlarge size.
Fillodes tumor treatment include lump removal through surgery. After surgery, the possibility of recurrence is still there.
Breast cancerBreast cancer is a malignant lump is often painless, palpable hard and irregularly shaped.
At the touch, this lump feels different from surrounding breasttissue. If the lump is attached to the chest muscles, the lump can not be driven.
Skin over the lump may be interested and reddish.
Another feature of breast cancer, among others, is a discharge ofclear fluid or blood mixed spontaneously from the nipples, nipplesappear to be interested, change size and shape of the breast, andbreast skin like orange peel.
Breast cancer treatment depends on the type of cancer, cancer staging, and description of the cancer cells look under amicroscope.
Treatment options may include surgery, radiation, chemotherapy,or hormone therapy.
Keep in mind that breast cancer is discovered at an early stage, chances for successful treatment of breast cancer greater than thatfound in an advanced stage.

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Breast Self-Examination


* Standing in front of the mirror with her ​​hands placed on the side of the body.
Raise both arms and observe carefully the skin on the breast if there are wrinkles, curves, change in size or shape.
See if there is a change of symmetry in both breasts.
Observe also if the nipple or enter into any strange fluid coming out of the nipple.
Now put both hands on the side pingul then observe your breasts.After that put both hands behind your head and do the same.

* Check both breasts while standing in the shower while showering.Do the same when you lie.
Put one hand behind his head, one hand while doing the massagemotion rotate clockwise in the area of ​​breast tissue, nipple, and thetissue under the armpit.
Repeat this on the left breast. When you do the bath, soaps andwater makes the skin smooth up to mampermudah examination.


* Check if there are lumps that do not disappear or do not change.An abnormal lump can appear suddenly and persist.
These lumps of different shapes and hardness and sometimesfeels hard with irregular edges.
Sometimes the lump is a thickening of the tissue without a clearboundary line. Remember, the cancerous lump is usually painless.

American Cancer Society recommends women undergo clinicalbreast examination as part of routine health examinations, onceevery three years for women aged 20-39 years and every year for women over 40 years.

T 0: not found the primary tumor
Q 1: The size of the tumor diameter of 2 cm or less
T 2: tumor size of 2-5 cm diameter
Q 3: The size of the tumor diameter> 5 cm
Q 4: How tumor size alone, but there have been spread to the skinor chest wall or both, may include ulcers,  edema, or swelling, breast skin redness or a small lump on the skin outside the main tumor

Stadium 0: T0 N0 M0
Stadium 1: T1 N0 M0
Stadium II A: T0 N1 M0 / T1 N1 M0 / T2 N0 M0
Stadium IIB: T2 N1 M0 / T3 N0 M0
Stadium IIIA: T0 N2 M0 / T1 N2 M0 / T2 N2 M0 / T3, N1, M0 / T2 N2M0
Stadium IIIB: T4 N0 M0 / N1 M0 T4 / T4 N2 M0
Stadium III C: every T N3 M0
Stadium IV: every T-M1-N

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Management of Treatment

In many cases, doctors will work with patients to determine thetreatment plan Although the treatment of each patient will be adjusted by the doctor.
But here are the general steps undertaken in the treatment ofbreast cancer:

* The main purpose of early-stage cancer treatment is to remove the tumor and tissue surrounding the tumor.
So doctors will recommend surgery to remove the tumor. Generally,radiation therapy will then be performed on the remaining breasttissue.
For certain circumstances (eg, patients with serious medicalproblems) radiation can be postponed.
* The following steps in dealing with early stage cancer is to reducethe risk cancer will recur and discard the remaining cancer cells.
When the tumor is large lymph nodes or channels have beenstricken with cancer as well, the doctor will recommend additionaltherapy, among others: Radiation Therapy, Chemotherapy, and / orhormone therapy.
As for the recurrence of cancer, treated with a variety of ways.When planning treatment, doctors will consider several factors:

* Stage and grade of cancer
* Status of the tumor hormone receptor (ER, PR) and HER2/neustatus
* Age of patients and the general health
* Patients have gone through menopause or not
* The presence of gene mutations of breast cancer biology breast cancer condition an effect on the behavior of the cancer and its treatment.
Some tumors are small in size but growing in size fast or big butslow growth.


Treatment usually begins after a thorough assessment of the condition of the patient, which is about a week or more after thebiopsy.
Treatment consists of surgery, radiation therapy, chemotherapyand hormone inhibitors.

Radiation therapy is used to kill cancer cells in the removal of the tumor and the surrounding area, including the lymph nodes.

Chemotherapy (a combination of drugs to kill cells that multiplyquickly or pressing breeding) and drug-hormone inhibitors (drugs that affect the hormones that promote the growth of cancer cells)are used to suppress the growth of cancer cells throughout thebody.

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Symptoms and Signs of Breast Cancer


For the early symptoms include a lump usually feels different fromsurrounding breast tissue, painless and usually have an irregular edge.

In the early stages, when driven by a finger, a lump can be moved easily under the skin.
In later stages, the lump usually adheres to the chest wall or skinaround it. In advanced cancer, can form a swollen lump or breast skin ulcers.
Sometimes the skin over the lump shrank and looked like an orange peel.

Other symptoms that may be found a lump or mass in the armpit,change size or shape of the breast, an abnormal discharge from the nipple (usually bloody or yellow to green, may also be pus), change incolor or texture of the skin on the breast, nipple and areola (dark brown colored area around the nipple), breast looks red, the skin around the nipple scaly nipple interestedin or feel itching, breast tenderness or swelling of one breast.

At an advanced stage may develop bone pain, weight loss,swelling of arms or ulcerated skin.

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